Evidence-Based Practice: Clinical Trials

Searching for evidence

Facts and Myths [Source: Dollar photo club, https://www.dollarphotoclub.com/]

Why search them?

A big category of grey literature, particularly for clinical research is clinical trials.

Searching registers for ongoing trials and trials with negative results is critical.

Finding out about unpublished studies, and including them in a systematic review when eligible and appropriate, is important for minimizing bias. Ongoing trials should be identified and tracked for possible inclusion in reviews on completion.

Jeremy M Farmer, Index to Marriage Register - Cook County, Oct 9 2009, CC license 2.0 Generic (CC BY-NC-ND 2.0) (https://creativecommons.org/licenses/by-nc-nd/2.0/deed.en), Image source: Flickr (https://www.flickr.com/photos/farmdog/4011997478/)

Key starters

World map [Image source: Pixabay, https://pixabay.com/en/map-world-motley-rainbow-texture-1247143/, copied under CC0 1.0 Public domain dedication, https://creativecommons.org/publicdomain/zero/1.0/deed.en]World Health Organization's International Clinical Trials Registry Platform

Search many key registries from around the world. This includes the:

  • Australian New Zealand Clinical Trials Registry (ANZCTR)
  • Clinical Trials.gov (Unites States)
  • EU Clinical Trials Register (EU-CTR)

Note: the search portal will tell you when data is updated from the different data providers. You may also want to search individual registries.

Australian New Zealand Clinical Trials Registry

Australia [Image source adapted from: Pixabay, https://pixabay.com/en/map-world-motley-rainbow-texture-1247143/, copied under CC0 1.0 Public domain dedication, https://creativecommons.org/publicdomain/zero/1.0/deed.en]
Trials at UniSA

University of South Australia staff and students undertaking a project that is a clinical trial will be required to register it in a publicly accessible trials registry prior to enrollment of the first participant, e.g. Australian New Zealand Clinical Trials Registry as a condition of ethics approval.

Clinical Trials.gov

European Union Clinical Trials Register

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More registers